OVERVIEW OF OUR INTEGRATED SYSTEMS BIOLOGY APPROACH
We are working towards molecular-based disease stratification.
Our general approach involves correlating clinical, molecular, and histopathologic phenotyping, along with validation in model systems.
RESEARCH NEWS
SARS-CoV-2 receptor networks in diabetic kidney disease, BK-Virus nephropathy and COVID-19 associated acute kidney injury [KI in review]
Making patients resilient to COVID-19: Lessons to be learned from kidney single cell analysis
Matthias Kretzler presents an infrastructure to study a specific set of kidney rare diseases at Rare Disease Day.
Dr. Kretzler presented an introduction to the framework infrastructure used to study a specific set of kidney rare diseases at the Rare Disease Day conference last month.
Watch his presentation here.
Single Cell RNAseq Data Identifies Potential Endothelial Marker of FSGS Remission
The Kidney Precision Medicine Project (KPMP) and the Nephrotic Syndrome Study Network (NEPTUNE) recently published a landmark study in the journal JCI Insight. This work highlights the relevance of a new and emerging technology in exposing underlying mechanisms involved in kidney disease progression.
How the UMMS Central Biorepository Can Benefit Your Research
University of Michigan Medical School Office of Research recently published a video featuring the UMMS Central Biorepository (CBR). Director Victoria Blanc, Ph.D., walks through the process of accessing and storing biospecimens and MiKTMC’s Matthias Kretzler, MD speaks about how the samples from our cohort study networks across the world are managed using the CBR.
Funding from NIH, U-M, and NephCure International to Support Research of Major Cause of Rare Kidney Diseases
The National Center for Advancing Translational Sciences (NCATS) and the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) recently awarded a third five-year cycle of funding to support the Nephrotic Syndrome Study Network (NEPTUNE), a member of the Rare Diseases Clinical Research Network (RDCRN).
The Nephrotic Syndrome Research Network is revolutionizing the field of glomerular kidney disease research
Now in its ninth year, the benefits of laying the groundwork for the Nephrotic Syndrome Research Network (NEPTUNE) are beginning to come into fruition. As NephCure CEO Josh Tarnoff notes, “It’s hard to overstate NEPTUNE’s impact on our understanding of FSGS and related syndromes. For example, one of the data sets presented by NEPTUNE at ASN Kidney Week 2016 provided the much-needed evidence correlating proteinuria levels to survival. This no doubt assisted the FDA to evolve their guidelines to accept proteinuria…
U-M ENTERS COLLABORATION TO DEVELOP TREATMENTS FOR CHRONIC KIDNEY DISEASE
Patients with Chronic Kidney Disease (CKD) may benefit from a new collaboration between U-M and AstraZeneca, who have partnered to develop a new therapeutic strategy for treatment. The partners will jointly conduct chemistry and drug discovery research with the aim of...
STILL GOING, GROWING STRONG: JOINT INSTITUTE CELEBRATES 7 YEARS WITH BEIJING SYMPOSIUM
As the world gets smaller, Michigan Medicine’s place in it gets bigger. That’s thanks to partnerships like the one which recently took nearly 80 faculty abroad to meet with research collaborators in China.
Investigation Of Kidney Biomarkers To Track Lupus Progression and Signs Of Complications
We recently collaborated with Emily Somers, Ph.D., Sc.M., an associate professor of internal medicine (rheumatology), environmental health sciences and obstetrics and gynecology at U-M and a member of the U-M Institute for Healthcare Policy and Innovation, to help...